Marco Romano was present at the 1540 muster as a member of Vázquez de Coronado's company. Given the elements of his name - Marco rather than Marcos, and Romano - referring to someone from Rome, it is highly likely that the expeditionary was from Italy.
1540-1550:
1540, Feb.: Muster in Flint & Flint, Documents, Document 12 [one horse, native arms, Vázquez de Coronado's company]
?Actas de Cabildo, Tomo IV, Book 7, p.101 [18 Jan-Marcos Romano has 1/2 solar, vecino, un pedazo de solar in the barrio of San Sebastian, linda con casas de Ana india and Martín indio jubetero and por delante la calle que va de las casas del Licencado Sandoval hacia el acequia que pasa por las espaldas de San Sebastian church que va por las espaldas de Santo Domingo convent]
Relatives?: AGI, Justicia, 268, N.2, Pieza 2 [1544, Gabriel de Castellanos con Juan de Sámano, alguacil major de México] [a Cosmé Romano is witness, estante en México, about 25 years old]